Pyrintegrin

Integrin and tyrosine kinase activator; Activates Integrin, FGFR, IGFR and HER2

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Integrin and tyrosine kinase activator; Activates Integrin, FGFR, IGFR and HER2
From: 168 USD

Overview

Pyrintegrin is a 2,4-disubstituted pyrimidine that  induces the activation of β1 integrin and multiple growth factor receptors, including FGFR1, IGFR1, EGFR1, and HER2 (Xu et al.).

MAINTENANCE AND SELF-RENEWAL
· Enhances integrin-dependent attachment and survival of human embryonic stem (ES) cells following trypsin-mediated single-cell dissociation (Xu et al.).
Alternative Names:
Not applicable
CAS Number:
1228445-38-2
Chemical Formula:
C₂₃H₂₅N₅O₃S
Molecular Weight:
451.5 g/mol
Purity:
≥ 95%
Pathway:
Tyrosine Kinase; Integrin
Target:
FGFR; HER2; IGFR; Integrin

Scientific Resources

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(4)

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Publications

(1)
Proceedings of the National Academy of Sciences of the United States of America 2010 MAY

Revealing a core signaling regulatory mechanism for pluripotent stem cell survival and self-renewal by small molecules.

Xu Y et al.

Abstract

Using a high-throughput chemical screen, we identified two small molecules that enhance the survival of human embryonic stem cells (hESCs). By characterizing their mechanisms of action, we discovered an essential role of E-cadherin signaling for ESC survival. Specifically, we showed that the primary cause of hESC death following enzymatic dissociation comes from an irreparable disruption of E-cadherin signaling, which then leads to a fatal perturbation of integrin signaling. Furthermore, we found that stability of E-cadherin and the resulting survival of ESCs were controlled by specific growth factor signaling. Finally, we generated mESC-like hESCs by culturing them in mESC conditions. And these converted hESCs rely more on E-cadherin signaling and significantly less on integrin signaling. Our data suggest that differential usage of cell adhesion systems by ESCs to maintain self-renewal may explain their profound differences in terms of morphology, growth factor requirement, and sensitivity to enzymatic cell dissociation.
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.