Human Recombinant BAFF

B cell activating factor

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B cell activating factor
From: 111 USD

Overview

B cell activating factor (BAFF) is part of the tumor necrosis factor (TNF) superfamily and is expressed by monocytes, macrophages, dendritic cells, and neutrophils (Mackay & Browning; Scapini et al.). It binds to 3 receptors: BAFF-R, TACI, and BCMA, all of which are expressed by B cells at various times in their development (Liu & Davidson). BAFF-R signaling activates the NF-kB signaling pathway, and promotes B cell survival, Ig class switching, and antigen presentation (Bossen & Schneider; Liu & Davidson; Naradikian et al.). BAFF also has functions in other cell types: it promotes monocyte survival and activation, proinflammatory cytokine secretion, and differentiation into macrophages (Chang et al.), and co-stimulates anti-CD3-mediated activation of human T cells (Huard et al.; Mackay & Leung).
Alternative Names:
BLyS, TALL1, TNFSF13B
Cell Type:
B Cells
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
17 kDa
Purity:
> 95%

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(2)

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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Data

(A) The biological activity of Human Recombinant BAFF was tested by its ability to promote mitosis of RPMI-8226 cells. Mitogenic activity was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which mitogenic activity is at 50% of maximum. The EC50 in the above example is less than 20 ng/mL.
(B) 1 μg of Human Recombinant BAFF was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions visualized by Coomassie Blue staining. Human Recombinant BAFF has a predicted molecular mass of 17 kDa.

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