Mouse Recombinant TRAIL

TNF-related apoptosis-inducing ligand

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TNF-related apoptosis-inducing ligand
From: 80 USD

Overview

TRAIL (TNF-related apoptosis-inducing ligand) belongs to the tumor necrosis factor (TNF) superfamily and is associated with initiating apoptosis. TRAIL has four major receptors: two death receptors DR4 and DR5, and two decoy receptors DcR1 and DcR2. TRAIL binds to the death receptors, which recruits the Fas-associated death domain (FADD) and activates caspases 8 and 10, which eventually leads to apoptosis (Pitti et al.; Wiley et al.; Zauli & Secchiero). It has been shown that mice lacking the expression of TRAIL have defects in thymocyte apoptosis and negative selection, and these mice had increased susceptibility to autoimmune diseases (Lamhamedi-Cherradi et al.).
Alternative Names:
TL2, TNF-related apoptosis-inducing ligand, TNFSF10
Cell Type:
T Cells
Species:
Mouse
Area of Interest:
Immunology
Molecular Weight:
20 kDa
Purity:
≥ 98%

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Educational Materials

(1)

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Data and Publications

Data

(A) The biological activity of Mouse Recombinant TRAIL was tested by its ability to inhibit the proliferation of RPMI-8226 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 100 ng/mL. (B) 2 μg of Mouse Recombinant TRAIL was resolved with SDS-PAGE under reducing (+) conditions and visualized by Coomassie Blue staining.

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