Human Recombinant VEGF-C

Vascular endothelial growth factor C

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Vascular endothelial growth factor C
From: 94 USD

Overview

Vascular endothelial growth factor C (VEGF-C) is a member of the VEGF/platelet-derived growth factor (PDGF) family of proteins. VEGF-C is a potent angiogenic factor and promotes lymphangiogenesis, endothelial cell growth and survival, and can affect blood vessel permeability. VEGF-C is expressed in a range of tissues, but is not expressed in peripheral blood lymphocytes. VEGF-C forms a non-covalent, cell surface-associated, disulfide-linked homodimer that can bind and activate VEGF receptors 2 (VEGFR-2 [Flk1]) and 3 (VEGFR-3 [Flt4]). Interaction with VEGFR-2 results in physiological and intratumoral neoangiogenesis and vessel sprouting (Cao et al.; Tammela et al.), whereas interaction with VEGFR-3 is critical for lymphangiogenesis (Karkkainen et al.; Laakkonen et al.; Mäkinen et al.). Overexpression of VEGF-C in tumor cells has been shown to result in enhanced lymph flow and increased metastasis to regional lymph nodes (Hoshida et al.; Mandriota et al.; Padera et al.; Skobe et al.).
Alternative Names:
Flt4-L, Flt4 ligand, Vascular endothelial growth factor C, Vascular endothelial growth factor-related protein, VRP
Cell Type:
Endothelial Cells
Species:
Human
Area of Interest:
Endothelial Cell Biology
Molecular Weight:
13.2 kDa
Purity:
≥ 95%

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Data and Publications

Data

(A) The biological activity of Human Recombinant VEGF-C was tested by its ability to promote the proliferation of HUVECs. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is less than 500 ng/mL. (B) 2 μg of Human Recombinant VEGF-C was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant VEGF-C has a predicted molecular mass of 13.2 kDa.

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