Human Recombinant IL-1 alpha

Interleukin 1 alpha

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Interleukin 1 alpha
From: 197 USD

Overview

Interleukin 1 alpha (IL-1α) is a member of the IL-1 family and a dual-function cytokine. Both the unprocessed precursor and a processed IL-1α protein signal through IL-1 receptor type 1 (IL-1R1). Various cells, including keratinocytes, thymic epithelium, hepatocytes, endothelial cells, fibroblasts, and the epithelial cells of mucous membranes, have high levels of intracellular IL-1α precursor. The precursor is also expressed on the surface of monocytes and B lymphocytes (Netea et al.). IL-1α recruits infiltrating cells to a site of injury during necrosis and plays an important role during processes of sterile inflammation (Cohen et al.; Rider et al.). During hypoxia, IL-1α contributes to angiogenesis (Carmi et al.). Studies in mice show that IL-1α is produced by microglia-like cells after ischemic brain injury, which contributes to the inflammation (Luheshi et al.).
Alternative Names:
BAF, B-cell-activating factor, Epidermal cell-derived thymocyte-activating factor, ETAF, FAF, Fibroblast-activating factor, IL-1F1, LAF, LEM, Leukocyte Endogenous Mediator, Lymphocyte-activating factor, MCF, Mononuclear Cell Factor
Cell Type:
B Cells; T Cells; Monocytes
Species:
Human
Area of Interest:
Immunology
Molecular Weight:
18 kDa
Purity:
≥ 95%

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(1)

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Data and Publications

Data

(A) The biological activity of Human Recombinant IL-1 alpha was tested by its ability to promote the proliferation of D10S cells. Cell proliferation was measured after 42 hours using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 0.68 pg/mL. (B) 1 μg of Human Recombinant IL-1 alpha was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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