CellPore™
CellPore™ Transfection System
Gentle Intracellular Delivery with High Efficiency and Viability
Intracellular delivery of molecules is crucial for advancing biological research and developing innovative cell and gene-based therapies. Traditional methods for transfecting cells are often limited in their ability to deliver a wide range of cargoes across diverse cell types. Additionally, these methods can inadvertently alter gene expression and disrupt cell function.
To address your cell engineering needs, we developed the CellPore™ Transfection System—an instrument offering versatility in delivering a variety of macromolecules into the cytosol of cells. Using gentle microfluidic technology, the system provides a simple, intuitive workflow that can be tailored to your specific research applications.
How Does CellPore™ Work?
Consisting of a benchtop instrument, the system uses pressure to squeeze the cells at high speeds through parallel microfluidic channels embedded in a single-use delivery cartridge (included in the CellPore™ Transfection Kits). This creates transient cell membrane pores, a process known as mechanoporation, which enables the entry of target cargoes into the cytosol before the membrane reseals.
Why Use CellPore™?
- Achieve high delivery and viability for your cells
- Fine-tune a single parameter to identify optimal delivery and viability conditions
- Deliver cargoes intracellularly without altering cell quality
- Transfect up to 10 million cells per second
- Deliver a wide variety of cargoes to a broad range of cell types
Figure 1. CellPore™ Transfection System Workflow
This figure illustrates the CellPore™ Transfection System workflow in three straightforward steps: 1) prepare cells sourced from freshly isolated or frozen samples using cell isolation technology such as EasySep™; 2) deliver one or more desired cargoes into your cells using the CellPore™ Transfection System; 3) analyze the delivery efficiency for downstream applications.
CellPore™ Products
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The purchase of a CellPore™ Transfection System, CellPore™ Delivery Cartridges, and associated reagents (“CellPore™ Products”) conveys to the purchaser a limited, non-exclusive, non-transferable license to use CellPore™ products, in accordance with STEMCELL’s Terms and Conditions of Sale (www.stemcell.com/terms-and-conditions-general) and all applicable laws and regulations, and solely for research-use-only applications (which applications exclude any commercial application or any therapeutic, prophylactic, diagnostic application, as well as any development and/or commercialization of products therewith or developed therefrom). STEMCELL or its licensor(s) grant no additional license rights other than those explicitly granted herein, and except for such limited license rights, all other intellectual property and proprietary rights in and to CellPore™ products are and shall remain the exclusive property of STEMCELL and its licensors. The purchaser of CellPore™ products agrees to prevent unauthorized use, access, copying, or disclosure of any intellectual property comprised in CellPore™ products. The purchaser shall not, and shall not permit anyone to copy, create any derivative work, reverse engineer, disassemble, decompile, or make improvements to CellPore™ products. Users and purchasers of CellPore™ products hereby grant to STEMCELL exclusive ownership and all rights, title, and interest in and to any improvements made, by purchasers or users, to the CellPore™ products (including any improvements by purchasers or users to the intellectual property directly related to CellPore™ products), provided however that the user or purchaser who makes the improvement retains a limited, non-transferable license to use such improvement for its internal, non-commercial research use, in accordance with this agreement, only so long as such user or purchaser is in compliance with this agreement. All data, information, and results (to the extent they do not constitute improvements of CellPore™ products) entered, stored, compiled, generated, and/or analyzed by purchasers of CellPore™ products using the CellPore™ products in accordance with all of the foregoing shall be the property of such purchaser.
CellPore™ Transfection System and CellPore™ Delivery Cartridges (“CellPore™ products”) are protected by patents in the U.S. and elsewhere. More information can be found at https://www.cellpore.com. The list of products and patents contained therein are subject to change as a result of routine prosecution and dependent on the patent life cycle as determined by the laws of each jurisdiction in which a relevant patent is in effect.
Quality Statement:
UNLESS OTHERWISE STATED, PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES. FOR PRODUCT-SPECIFIC COMPLIANCE AND INTENDED USE INFORMATION, REFER TO THE PRODUCT INFORMATION SHEET. GENERAL INFORMATION ON QUALITY AT STEMCELL MAY BE FOUND AT WWW.STEMCELL.COM/COMPLIANCE.
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