Anti-SHIP Antibody, Polyclonal

Rabbit polyclonal antibody against mouse SHIP

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1,146 USD

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Rabbit polyclonal antibody against mouse SHIP
1,146 USD

Overview Related Products Scientific Resources Data and Publications

Overview

SH2-containing inositol phosphatase (SHIP) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse full-length SHIP protein, 145 kDa, as well as the C-terminal truncated 135, 125, and 110 kDa forms.
Subtype:
Primary Antibodies
Target Antigen:
SHIP
Alternative Names:
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; p150Ship; SHIP1; SHIP-1; s-SHIP; SIP-145
Reactive Species:
Mouse; Human
Conjugation:
Unconjugated
Host Species:
Rabbit
Cell Type:
Granulocytes and Subsets; Lymphocytes; Myeloid Cells
Application:
Immunoblotting; Immunoprecipitation
Area of Interest:
Immunology
Clone:
Not applicable
Gene ID:
16331
Isotype:
Not applicable

Scientific Resources

Product Documentation

Educational Materials

(2)
Brochure
Complete Antibody Listing
Wallchart
Human Immune Cytokines

Data and Publications

Data

Western blot analysis of mouse bone marrow derived mast cells (BMMCs) from normal (+/+) and SHIP knockout (-/-) mice with Anti-SHIP Antibody, Polyclonal (1:4000 dilution). SHIP has a predicted molecular mass of 145 kDa.

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