Anti-SHIP Antibody, Polyclonal
Rabbit polyclonal antibody against mouse SHIP
Overview
SH2-containing inositol phosphatase (SHIP) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse full-length SHIP protein, 145 kDa, as well as the C-terminal truncated 135, 125, and 110 kDa forms.
Subtype
Primary Antibodies
Target Antigen
SHIP
Alternative Names
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; p150Ship; SHIP1; SHIP-1; s-SHIP; SIP-145
Reactive Species
Human, Mouse
Conjugation
Unconjugated
Host Species
Rabbit
Cell Type
Granulocytes and Subsets, Lymphocytes, Myeloid Cells
Species
Human, Mouse
Application
Immunoblotting, Immunoprecipitation
Area of Interest
Immunology
Clone
Not applicable
Gene ID
16331
Isotype
Not applicable
Related Products
Related Products
Scientific Resources
Product Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
Anti-SHIP Antibody, Polyclonal
Catalog #
60141 Lot #
All Language
English Document Type
Safety Data Sheet
Product Name
Anti-SHIP Antibody, Polyclonal
Catalog #
60141 Lot #
All Language
English Educational Materials (2)
Data and Publications
Western blot analysis of mouse bone marrow derived mast cells (BMMCs) from normal (+/+) and SHIP knockout (-/-) mice with Anti-SHIP Antibody, Polyclonal (1:4000 dilution). SHIP has a predicted molecular mass of 145 kDa.
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
