GANT 58

Hedgehog pathway inhibitor; Inhibits GLI1

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Hedgehog pathway inhibitor; Inhibits GLI1
From: 79 USD

Overview

GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).


CANCER RESEARCH
· Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).
· Inhibits prostate cancer tumor growth (Lauth et al.).
· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
Alternative Names:
NSC 75503
CAS Number:
64048-12-0
Chemical Formula:
C₂₄H₁₆N₄S
"
Molecular Weight:
392.5 g/mol
Purity:
≥ 98%
Pathway:
Hedgehog
Target:
GLI

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.