GANT 58
Hedgehog pathway inhibitor; Inhibits GLI1
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GANT 58 -
GANT 58 -
Label for GANT 58 -
Label for GANT 58
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Overview
GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).
CANCER RESEARCH
· Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).
· Inhibits prostate cancer tumor growth (Lauth et al.).
· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
CANCER RESEARCH
· Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).
· Inhibits prostate cancer tumor growth (Lauth et al.).
· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
Alternative Names:
NSC 75503
CAS Number:
64048-12-0
Chemical Formula:
C₂₄H₁₆N₄S
"Molecular Weight:
392.5 g/mol
Purity:
≥ 98%
Pathway:
Hedgehog
Target:
GLI
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Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
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