GANT 58
Hedgehog pathway inhibitor; Inhibits GLI1
-
GANT 58 -
GANT 58 -
Label for GANT 58 -
Label for GANT 58
More Views
Overview
GANT 58 inhibits the Hedgehog signaling pathway downstream of Smoothened and Suppressor of Fused (SUFU) leading to GLI1 nuclear accumulation (Joo et al.; Stanton & Peng). GANT 58 demonstrates antiproliferative and antitumor activity in vivo (Beauchamp et al.; Joo et al.).
CANCER RESEARCH
· Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).
· Inhibits prostate cancer tumor growth (Lauth et al.).
· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
CANCER RESEARCH
· Reduces anchorage-independent growth in Ewing Sarcoma cells (Beauchamp et al.; Joo et al.).
· Inhibits prostate cancer tumor growth (Lauth et al.).
· Causes cell cycle arrest and apoptosis in acute leukemia T cells (Hou et al.).
Alternative Names:
NSC 75503
CAS Number:
64048-12-0
Chemical Formula:
C₂₄H₁₆N₄S
"Molecular Weight:
392.5 g/mol
Purity:
≥ 98%
Pathway:
Hedgehog
Target:
GLI
Related Products
-
For culture of human mammary epithelial cells -
For culture and evaluation of human mammary epithelial cells in CFU assays -
For culture of human mammospheres and tumorspheres
Scientific Resources
Product Documentation
Document Type
Product Name
Catalog #
Lot #
Language
Educational Materials
(5)
Product Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.