D4476

Activin/NODAL/TGF-β pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK
Catalog #
74012_C
Activin/NODAL/TGF-β pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK
From: 128 USD

Overview

D4476 is a selective, potent, and cell-permeant inhibitor of casein kinase (CK) 1 (Rena et al.). It inhibits CK1 and CK1δ from S. pombe (IC50 = 200 nM and 300 nM, respectively; Bain et al.; Rena et al.). It also inhibits transforming growth factor β1 (TGF-β1) type I receptor (ALK5) with IC50 = 500 nM (Rena et al.).

REPROGRAMMING
· Along with forskolin (Catalog #72112) and 2-methyl-5-hydroxytryptamine, reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).

· Reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).


CANCER RESEARCH
· Induces apoptosis of multiple myeloma cell lines (Hu et al.).

· Exhibits anti-leukemic activity by selectively killing leukemia stem cells over normal hematopoietic stem and progenitor cells (Järås et al.).
Alternative Names
Casein Kinase I Inhibitor
Cell Type
Hematopoietic Stem and Progenitor Cells, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Reprogramming
Area of Interest
Cancer, Stem Cell Biology
CAS Number
301836-43-1
Chemical Formula
C₂₃H₁₈N₄O
"
Molecular Weight
398.4 g/mol
Purity
≥ 98%
Pathway
Activin/Nodal/TGFβ, p38 MAPK
Target
ALK5

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
D4476
Catalog #
74012
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
D4476
Catalog #
74012
Lot #
All
Language
English

Educational Materials (3)

Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Wallchart
Small Molecules, Big Impact in Cancer Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.