Geldanamycin

Inhibits Hsp90

Geldanamycin

Inhibits Hsp90

From: 113 USD
Catalog #
74032_C
Inhibits Hsp90

Overview

Geldanamycin is a benzoquinone ansamycin antibiotic that selectively inhibits heat shock protein 90 (Hsp90) (Schulte et al.; Whitesell et al.). It inhibits the ATPase activity of Hsp90 by binding with high affinity to the N-terminal ATP-binding site (Kd = 1.2 µM; Roe et al.). Geldanamycin also binds to the glucose-regulated protein GRP94, an endoplasmic reticulum protein with homology to Hsp90. This interaction destabilizes its complex with p185-ERBB2 leading to degradation of ERBB2 protein, which is overexpressed in aggressive breast cancers (Chavany et al.; Castagnola et al.).



CANCER RESEARCH
· Inhibits growth of 60 human tumor cell lines (Supko et al.).

DISEASE MODELING

· Regulates innate immune response as demonstrated by inhibition of inflammasome activity in a mouse gout model (Mayor et al.).
· Inhibits replication of HSV-1 and HSV-2 (Li et al.).
Alternative Names
NSC 122750
Cell Type
Cancer Cells and Cell Lines, Monocytes
Species
Human, Mouse, Rat, Non-Human Primate, Other
Area of Interest
Cancer, Disease Modeling, Immunology
CAS Number
30562-34-6
Chemical Formula
C₂₉H₄₀N₂O
"
Molecular Weight
560.6 g/mol
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
Geldanamycin
Catalog #
74032, 74034
Lot #
All
Language
English
Product Name
Geldanamycin
Catalog #
74032, 74034
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Geldanamycin
Catalog #
74032, 74034
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

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