Mouse Recombinant FGF-21

Fibroblast growth factor 21
Catalog #
78108_C
Fibroblast growth factor 21
From: 317 USD

Overview

Fibroblast growth factor 21 (FGF-21) is a member of the FGF family. Using β-Klotho as a cofactor, FGF-21 signals through FGF receptor 1c and 4 to activate PI3K and MAPK pathways (Mattila & Härkönen; Kharitonenkov et al.). FGF-21 expression is regulated by tissue-specific peroxisome proliferator-activated receptors (PPARs). Upon PPAR-α stimulation FGF-21 is produced in the liver, and activation of PPAR-γ leads to FGF-21 production in adipose tissue. FGF-21 promotes insulin-independent glucose uptake and lipid accumulation in primary human adipocytes and in mouse 3T3-L1 cells. In pancreatic islets and INS-1 cells it inhibits glucose-mediated glucagon release and stimulates insulin production. FGF-21 does not induce proliferation in immortalized cell lines, unlike other FGFs (Kharitonenkov & Shanafelt). FGF-21 regulates thermogenesis in white and brown adipose tissue, and metabolic processes in cells of pancreatic origin (Kharitonenkov et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
Fibroblast growth factor 21
Cell Type
Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Mammary Cells, Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, Prostate Cells
Species
Mouse
Area of Interest
Epithelial Cell Biology, Neuroscience, Stem Cell Biology
Molecular Weight
19.9 kDa
Purity
≥ 97%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Mouse Recombinant FGF-21
Catalog #
78108.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Mouse Recombinant FGF-21
Catalog #
78108.1
Lot #
All
Language
English

Educational Materials (6)

Brochure
Cytokines, Chemokines and Growth Factors
Brochure
hPSC-Derived Neural Cell Research
Brochure
Mammary Epithelial Cells: Standardized Media and Reagents
Brochure
Products for Human Pluripotent Stem Cells
Brochure
Standardized Solutions for Mouse Pluripotent Stem Cells
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Mouse Recombinant FGF-21 was tested by its ability to promote the proliferation of NIH-3T3 cells in the presence of 1.25 μg/mL mouse Klotho and 10 μg/mL heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.5 μg/mL. (B) 2 μg of Mouse Recombinant FGF-21 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Contact STEMCELL Technologies

Our Customer Service, Sales, and Product and Scientific Support departments in North America are available between 6 am and 5 pm Pacific Time (9 am and 8 pm Eastern Time). One of our representatives will be happy to help you by telephone or email. Please complete the form to contact us by email. A representative will get back to you shortly.
  •  

StemCell Technologies Inc. and affiliates ("STEMCELL Technologies") does not share your email address with third parties. StemCell Technologies Inc. will use your email address to confirm your identity and send you newsletters, transaction-related emails, promotional and customer service emails in accordance with our privacy policy. You can change your email preferences at any time.