Mouse Recombinant FGF-21

Fibroblast growth factor 21

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Mouse Recombinant FGF-21

Fibroblast growth factor 21

From: 376 USD

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50 µg

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Fibroblast growth factor 21

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Overview

Fibroblast growth factor 21 (FGF-21) is a member of the FGF family. Using β-Klotho as a cofactor, FGF-21 signals through FGF receptor 1c and 4 to activate PI3K and MAPK pathways (Mattila & Härkönen; Kharitonenkov et al.). FGF-21 expression is regulated by tissue-specific peroxisome proliferator-activated receptors (PPARs). Upon PPAR-α stimulation FGF-21 is produced in the liver, and activation of PPAR-γ leads to FGF-21 production in adipose tissue. FGF-21 promotes insulin-independent glucose uptake and lipid accumulation in primary human adipocytes and in mouse 3T3-L1 cells. In pancreatic islets and INS-1 cells it inhibits glucose-mediated glucagon release and stimulates insulin production. FGF-21 does not induce proliferation in immortalized cell lines, unlike other FGFs (Kharitonenkov & Shanafelt). FGF-21 regulates thermogenesis in white and brown adipose tissue, and metabolic processes in cells of pancreatic origin (Kharitonenkov et al.).

Cytokines, Growth Factors

Fibroblast growth factor 21

Endoderm, PSC-Derived, Hematopoietic Stem and Progenitor Cells, Mammary Cells, Mesenchymal Stem and Progenitor Cells, Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Pluripotent Stem Cells, Prostate Cells

Mouse

Epithelial Cell Biology, Neuroscience, Stem Cell Biology

19.9 kDa

≥ 97%

Data Figures

(A) The biological activity of Mouse Recombinant FGF-21 was tested by its ability to promote the proliferation of NIH-3T3 cells in the presence of 1.25 μg/mL mouse Klotho and 10 μg/mL heparin. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.5 μg/mL. (B) 2 μg of Mouse Recombinant FGF-21 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

Catalog #

Lot #

Language

Document Type

Product Information Sheet

Product Name

Mouse Recombinant FGF-21

Catalog #

78108.1

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Mouse Recombinant FGF-21

Catalog #

78108.1

Lot #

All

Language

English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area

Workflow Stages

Workflow Stages for Mesenchymal Stem and Progenitor Cell Research

Cell Sourcing and Isolation

Culture and Cryopreservation

Differentiation

Characterization

Resources and Publications

Related Products

Quality Statement:

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Mouse Recombinant FGF-21

Fibroblast growth factor 21

Mouse Recombinant FGF-21

Fibroblast growth factor 21

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Overview

Data Figures

Protocols and Documentation

Applications

Resources and Publications

Educational Materials (5)

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