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The SN6h antibody reacts with CD105 (Endoglin), an ~180 kDa cell-surface glycoprotein that is a disulfide-bonded homodimer comprising ~90 kDa type I transmembrane subunits. CD105 is a component of the TGF-β receptor complex and is expressed by vascular endothelial smooth muscle cells, syncytiotrophoblasts of placenta, and activated macrophages, and at relatively low levels by stromal fibroblasts. Its expression is also observed in some types of tumors, and levels are up-regulated on the endothelium during angiogenesis. In concert with signaling receptors, CD105 binds to TGF-β1 and TGF-β3 with high affinity, but does not bind TGF-β2. Other ligands reportedly include Activin A, BMP-2, BMP-7, and BMP-9. CD105 has important roles in angiogenesis, cardiovascular development, and vascular remodeling, and the protein serves a regulatory role in cytoskeletal reorganization by modulating the sites of focal adhesion and cellular migration. Certain mutations in CD105 result in the autosomal dominant disorder hereditary hemorrhagic telangiectasia (HHT). The epitope of the SN6h antibody is reportedly localized within the Ala119-Gly230 sequence of the N-terminal OR1 (orphan region 1) domain. CD105 is often used in combination with CD73 and CD90 to phenotype mesenchymal stromal cells.
Phosphate-buffered solution, pH 7.2, containing 0.09%
sodium azide and 0.2% (w/v) bovine serum albumin
Figure 1. Flow cytometry analysis of different types of human mesenchymal stromal cells (MSCs)
Flow cytometry analysis of (A) human bone marrow-derived mesenchymal stromal cells (BM-MSCs), (B) human umbilical cord-derived mesenchymal stromal cells (UC-MSCs), (C) human adipose tissue-derived MSCs (ADSCs), (D) human induced pluripotent stem cell-derived mesenchymal progenitor cells (iPSC-MPCs), and (E) human dental pulp-derived mesenchymal stromal cells (DPSCs). The cells were cultured in MesenCult™-ACF Plus Medium (Catalog #05445) then labeled with Anti-Human CD105 (Endoglin) Antibody, Clone SN6h, APC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, APC (Catalog #60070AZ; solid line histogram).
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Medium for detection of CFU-F and expansion of human mesenchymal stem cells
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Anti-Human CD105 Antibody, Clone SN6h, APC
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