MLN4924

Inhibits NEDD8-activating enzyme

MLN4924

Inhibits NEDD8-activating enzyme

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Inhibits NEDD8-activating enzyme
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Overview

MLN4924 inhibits cullin neddylation by directly targeting the NEDD8-activating enzyme that is essential for the activity of cullin-RING ligase (CRL) (Nawrocki et al.). The components of CRL are frequently up-regulated in human cancers (Zhao & Sun), and MLN4924 was reported to suppress the growth of human tumor xenografts in mice (Soucy et al.).


GENOME EDITING
· In combination with other small molecules (“CRISPY” mix), MLN4924 has been reported to increase precise CRISPR-Cas9 genome editing in human pluripotent stem cells (Riesenberg & Maricic).

CANCER RESEARCH
· By blocking NAE and proteasome, MLN4924 together with bortezomib inhibits AKT and mTOR and induces apoptosis in multiple myeloma cell lines (Gu et al.).
Cell Type
Cancer Cells and Cell Lines, Myeloid Cells, Pluripotent Stem Cells
Species
Human, Mouse, Non-Human Primate, Other, Rat
Application
Genome Editing
Area of Interest
Cancer, Stem Cell Biology
CAS Number
905579-51-3
Chemical Formula
C₂₁H₂₅N₅O₄S
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Product Name
MLN4924
Catalog #
74184, 74182
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
MLN4924
Catalog #
74184, 74182
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.