Human LDL

Low-density lipoproteins pre-screened for hematopoietic cell growth
Human LDL

Low-density lipoproteins pre-screened for hematopoietic cell growth

5 mg
Catalog # 02698
444 USD

Overview

This product is a human plasma-derived low-density lipoprotein (LDL)-based culture supplement that has been pre-screened for the culture, expansion, and colony assay of human hematopoietic and non-hematopoietic cells in serum-free culture media. It promotes the proliferation and survival of human hematopoietic and other progenitor cells in culture, resulting in increased cell output in expansion cultures and increased colony numbers and/or size in colony assays.
Contains
• A clear micro-emulsion of low-density lipoproteins in an aqueous solution
• 5 mg/mL protein as determined by modified Lowry Method using bovine serum albumin as a standard
Subtype
Supplements
Cell Type
Hematopoietic Stem and Progenitor Cells, Other
Species
Human
Application
Cell Culture

Related Products

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human LDL
Catalog #
02698
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human LDL
Catalog #
02698
Lot #
All
Language
English

Educational Materials(1)

Brochure
Hematopoietic Stem and Progenitor Cells - Products for Your Research

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

Importance of Low Density Lipoproteins

Figure 1. Importance of Low Density Lipoproteins

Effect of low density lipoproteins (LDLs) on megakaryocyte expansion in StemSpan™ H3000 supplemented with StemSpan™ Megakaryocyte Expansion Supplement

Publications (1)

Cell stem cell 2019 mar The NAD-Booster Nicotinamide Riboside Potently Stimulates Hematopoiesis through Increased Mitochondrial Clearance. N. Vannini et al.

Abstract

It has been recently shown that increased oxidative phosphorylation, as reflected by increased mitochondrial activity, together with impairment of the mitochondrial stress response, can severely compromise hematopoietic stem cell (HSC) regeneration. Here we show that the NAD+-boosting agent nicotinamide riboside (NR) reduces mitochondrial activity within HSCs through increased mitochondrial clearance, leading to increased asymmetric HSC divisions. NR dietary supplementation results in a significantly enlarged pool of progenitors, without concurrent HSC exhaustion, improves survival by 80{\%}, and accelerates blood recovery after murine lethal irradiation and limiting-HSC transplantation. In immune-deficient mice, NR increased the production of human leucocytes from hCD34+ progenitors. Our work demonstrates for the first time a positive effect of NAD+-boosting strategies on the most primitive blood stem cells, establishing a link between HSC mitochondrial stress, mitophagy, and stem-cell fate decision, and unveiling the potential of NR to improve recovery of patients suffering from hematological failure including post chemo- and radiotherapy.
View All Publications

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