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The 2B7 antibody reacts with CD235a (Glycophorin A), an ~10 kDa type I sialoglycoprotein present in the cell membrane of erythrocytes and erythroid precursors as a homodimer. Glycophorin A bears the antigenic determinants for the MN and Ss blood groups and has been proposed to provide a large mucin-like surface to erythrocytes that acts to minimize aggregation in circulation. Glycophorin A is first detectable on morphologically recognizable erythroid precursors just after the colony-forming unit erythroid (CFU-E) stage, and reaches its maximal expression at the late normoblast stage. Anti-glycophorin is useful in combination with anti-transferrin receptor (CD71) to identify distinct stages of erythroid differentiation since CD71 expression precedes Glycophorin A expression, but is lost during maturation of normoblasts into mature red blood cells (RBCs). Peptide-binding ELISA data indicate that the epitope of the 2B7 antibody is located in the extracellular domain of CD235a within the sequence Ala54 - Ser66 (AATPRAHEVSEIS).
Flow cytometry analysis of human whole blood labeled with Anti-Human CD235a (Glycophorin A) Antibody, Clone 2B7, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).
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Mouse monoclonal IgG1 antibody against human CD71 (transferrin receptor)
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Anti-Human CD235a (Glycophorin A) Antibody, Clone 2B7
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
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