Hematopoietic Stem and Progenitor Cell Research

A multipotent hematopoietic stem cell (HSC) is defined by the properties of self-renewal and differentiation into all of the different types of mature blood cells. See MoreAs HSCs divide, they progress through a series of lineage commitment steps, producing hematopoietic progenitor cells (HPCs) that are shorter lived and more restricted in their differentiation potential.

Whether you’re uncovering the mysteries of HSC biology, developing new cell therapies or manipulating cells with CRISPR-Cas9, the culture conditions you choose can make a difference in your experiments. Our serum-free media and premixed cytokine supplements provide optimized, highly reproducible culture conditions for your research.

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Brochure Small Molecules for HSPC Expansion: UM171 and UM729
Brochure StemSpan™ CD34+ Expansion Supplement
Brochure StemSpan™ Myeloid Expansion Supplement
Brochure StemSpan™ Erythroid Expansion Supplement
Brochure StemSpan™ Megakaryocyte Expansion Supplement

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Products

Cell Culture Media and Supplements 4 (28)

StemSpan™ NK Cell Generation Kit

For expansion and differentiation of human CD34+ hematopoietic progenitor cells to NK cells
StemSpan™ NK Cell Differentiation Supplement (100X)

Supplement for the differentiation of lymphoid progenitors to NK cells
StemSpan™ T Cell Progenitor Maturation Supplement (10X)

Supplement for the maturation of lymphoid progenitor cells to T cells
StemSpan™ Lymphoid Differentiation Coating Material (100X)

Coating material for the expansion and differentiation of lymphoid cells

Small Molecules 4 (15)

OAC1

Inducer of OCT4 expression
16,16-Dimethyl Prostaglandin E2

Prostanoid pathway activator; Inhibits 15-hydroxy PGDH
UM729

Pyrimido-indole derivative that enhances HSC self-renewal in vitro
Valproic Acid (Sodium Salt)

Epigenetic modifier; Inhibits histone deacetylase (HDAC)1

Cytokines and Proteins 4 (99)

Human Recombinant TGF-beta 1 (Cell Culture Ready)

Ready-to-use transforming growth factor beta 1
Human Recombinant IL-21, ACF

Interleukin 21, animal component-free
Human Recombinant VEGF-165, ACF

Vascular endothelial growth factor, animal component-free
Human Recombinant EPO

Erythropoietin

Cultureware and General Supplies 4 (5)

Corning® 245 mm Square Dish, Non-Treated

Square dish without handles
Corning® Disposable Erlenmeyer Flask, 500 mL

Sterile polycarbonate baffled Erlenmeyer flask for cell culture and sample storage
Falcon® 96-Well Flat-Bottom Microplate, Tissue Culture-Treated

Clear polystyrene flat-bottom, tissue culture-treated multiwell cell culture plate with lid
Falcon® 24-Well Flat-Bottom Plate, Tissue Culture-Treated

Clear polystyrene flat-bottom, tissue culture-treated multiwell cell culture plate with lid

Buffers and Solutions 4 (4)

Dulbecco's Phosphate Buffered Saline with 2% Fetal Bovine Serum

Cell culture buffer
HBSS, Modified (Without Ca++ and Mg++)

Hanks' Balanced Salt Solution (HBSS) without calcium and magnesium
HBSS with 10 mM HEPES, Without Phenol Red

Hanks' Balanced Salt Solution (HBSS) modified with 10 mM HEPES, without phenol red
D-PBS (Without Ca++ and Mg++)

Dulbecco’s phosphate-buffered saline without calcium and magnesium

Laboratory Equipment 4 (2)

Hausser Scientific™ Hemocytometer Cover Glasses

Replacement cover glasses for use with Hausser Scientific™ Hemocytometer
Hausser Scientific™ Bright-Line Hemocytometer

Counting chamber with 2 cover glasses

Training and Education 4 (1)

Pluripotent Stem Cell Training

Training to support the culture of hPSCs and their differentiation towards cerebral organoids, intestinal organoids, cardiomyocytes, or hematopoietic progenitors

Genome Editing and Molecular Tools 4 (1)

ArciTect™ Human CRISPR Optimization Kit

Complete kit for optimization of genome editing in human cells