Modeling Host-Microbe Interactions Using Human Intestinal Organoids
A common challenge to studying host-microbe interactions is the lack of optimal in vitro culture systems to recapitulate in vivo infection. In this virtual paper presentation, Dr. Devanjali Dutta discusses her research using human intestinal and lung organoids to study Cryptosporidium infection. Cryptosporidium is a protozoan parasite, a leading cause of diarrhea, and a major cause of child mortality worldwide. Dr. Dutta describes how she—and her colleagues in the lab of Dr. Hans Clevers—infected intestinal and lung organoids derived from healthy human donors with Cryptosporidium. In their paper*, organoids are presented as a physiologically relevant in vitro model to study Cryptosporidium and other pathogenic infections.
Dr. Devanjali Dutta is a Postdoctoral researcher in the lab of Dr. Hans Clever at the Hubrecht Institute.
*Heo I, Dutta D et al. (2018) Nat Microbiol. 3(7):814–23.
A common challenge to studying host-microbe interactions is the lack of optimal in vitro culture systems to recapitulate in vivo infection. In this virtual paper presentation, Dr. Devanjali Dutta discusses her research using human intestinal and lung organoids to study Cryptosporidium infection. Cryptosporidium is a protozoan parasite, a leading cause of diarrhea, and a major cause of child mortality worldwide. Dr. Dutta describes how she—and her colleagues in the lab of Dr. Hans Clevers—infected intestinal and lung organoids derived from healthy human donors with Cryptosporidium. In their paper*, organoids are presented as a physiologically relevant in vitro model to study Cryptosporidium and other pathogenic infections.
Dr. Devanjali Dutta is a Postdoctoral researcher in the lab of Dr. Hans Clever at the Hubrecht Institute.
*Heo I, Dutta D et al. (2018) Nat Microbiol. 3(7):814–23.
Publish Date:
January 14, 2019
Related Multimedia
-
Intestinal Organoid Culture: The Next Dimension in Intestinal Research
Publish Date: October 09, 2015 -
Patient-Derived Organoids for Drug Screening and Development
Publish Date: July 25, 2017 -
Organoid Expert Panel
Publish Date: August 30, 2018
Explore Our Products
-
Animal component-free, defined cryopreservation medium with 10% DMSO -
STEMdiff™ Gastric Organoid Differentiation Kit
Culture medium kit for differentiation of human gastric organoids -
IntestiCult™ Organoid Growth Medium (Mouse)
Cell culture medium for establishment and maintenance of mouse intestinal organoids -
Online and in-person training courses to support the culture of intestinal organoids
