Human Recombinant IL-13

Interleukin 13

Human Recombinant IL-13

Interleukin 13

From: 189 USD
Catalog #
78029_C
Interleukin 13

Overview

Interleukin 13 (IL-13) is a cytokine important in type 2 immune responses and is expressed by T helper type 2 (Th2) cells and group 2 innate lymphoid cells (ILC2s) (Pulendran & Artis). IL-13 binds a receptor composed of IL-4Ra and IL-13Ra1 or IL-13Ra2 (Wynn 2003). IL-13 receptor is expressed on B cells and promotes B cell proliferation, induces class switching to IgG4 and IgE, and functions in the recruitment and activation of IgE-producing B cells (Hershey). The receptor is also expressed on basophils, eosinophils, mast cells, endothelial cells, fibroblasts, monocytes, macrophages, respiratory epithelial cells, and smooth muscle cells (Hershey). Signaling through the IL-13 receptor activates the JAK/STAT and IRS-1/IRS-2 pathways. In vivo, IL-13 has a role in resistance to extracellular helminth parasites by regulating gastrointestinal parasite expulsion, as well as in airway hyperresponsiveness, allergic inflammation, tissue remodeling, tumor cell growth, and fibrosis (Wynn 2015). Secreted IL-13 is a protein consisting of 112 amino acids with a molecular mass of 10 kDa (Hershey). Human IL-13 is not species-specific but has greater activity on human cells compared to mouse cells (Hershey).
Subtype
Cytokines
Alternative Names
Interleukin-13, NC30
Cell Type
B Cells, Hematopoietic Stem and Progenitor Cells, Monocytes
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
12.6 kDa
Purity
≥ 95%

Scientific Resources

Product Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78029, 78029.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78029, 78029.1
Lot #
All
Language
English

Data and Publications

(A) The biological activity of Human Recombinant IL-13 was tested by its ability to promote the proliferation of TF-1 cells. Cell proliferation was measured after 62 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is 3 - 4 ng/mL.
(B) 1 ug of Human Recombinant IL-13 was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IL-13 has a predicted molecular mass of 12.6 kDa.

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