MAINTENANCE AND SELF-RENEWAL
· Promotes self-renewal and maintains mouse embryonic stem (ES) cells in an undifferentiated, pluripotent state in the absence of feeder cells, serum and leukemia inhibitory factor (LIF) for at least 10 passages (Chen et al.; Xiong et al.).
· When combined with LIF, improves efficiency of ES cell derivation from refractory mouse strains (Pieters et al.; Yang et al.).
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