NU7441

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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NU7441

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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Overview

NU7441 is an inhibitor of DNA-dependent protein kinase (DNA-PK), an enzyme involved in the non-homologous end joining (NHEJ) DNA repair pathway. It is highly selective for DNA-PK, with an IC₅₀ of 14 nM (Leahy et al.).

GENOME EDITING
·Reduces the frequency of NHEJ and increases the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Robert et al.).

CANCER RESEARCH
· Sensitizes human cancer cell lines to DNA double-strand-break-inducing therapies (chemo- or radio-therapy) by inhibiting DNA-PK activity and delaying the repair of double-strand breaks (Ciszewski et al.; Shaheen et al.; Yang et al.; Zhao et al.).

Cancer Cells and Cell Lines, Prostate Cells

Human, Mouse, Non-Human Primate, Other, Rat

Genome Editing

Cancer

503468-95-9

C₂₅H₁₉NO₃S

≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

Catalog #

Lot #

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Document Type

Product Information Sheet

Product Name

NU7441

Catalog #

74082, 74084

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

NU7441

Catalog #

74082, 74084

Lot #

All

Language

English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area

Workflow Stages

Workflow Stages for Mammary Epithelial Cell Research

Tissue Dissociation and Isolation

Cell Culture and Assay

Characterization

Workflow Stages for Genome Editing

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Resources and Publications

Quality Statement:

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.

NU7441

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

NU7441

NHEJ pathway inhibitor; Inhibits DNA-dependent protein kinase (DNA-PK)

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Overview

Protocols and Documentation

Applications

Resources and Publications

Educational Materials (3)

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