JAK Inhibitor I

JAK/STAT pathway inhibitor; Inhibits JAK1, JAK2, and JAK3

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JAK/STAT pathway inhibitor; Inhibits JAK1, JAK2, and JAK3
From: 128 USD

Overview

Janus Associated Kinase (JAK) Inhibitor I is a pyridine-containing tetracycle that disrupts JAK activity by interacting with the ATP binding domain. This inhibitor inhibits mouse JAK3 with Ki = 5 nM, JAK family members TYK2 and JAK2 with IC50 = 1 nM, and mouse JAK1 with IC50 = 15 nM, while showing weaker inhibition of other kinases (Thompson et al.).


REPROGRAMMING

· Inhibits the generation of mouse induced pluripotent stem cells (Efe et al.; Kim et al.).


IMMUNOLOGY

· Inhibits anti-viral response associated with JAK/STAT pathway activation (Xu et al.).
Alternative Names:
CMP 6; Janus-associated kinase inhibitor I; Pyridone 6
CAS Number:
457081-03-7
Chemical Formula:
C₁₈H₁₆FN₃O
"
Molecular Weight:
309.3 g/mol
Purity:
≥ 98%
Pathway:
JAK/STAT
Target:
JAK1; JAK2; JAK3

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Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.