Human Recombinant IFN-beta

Interferon-beta

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Interferon-beta
From: 84 USD

Overview

Interferon beta (IFN-β), also known as type I interferon, is produced by fibroblasts, and in smaller amounts by plasmocytoid dendritic cells. Macrophages and endothelial cells secrete IFN-β in response to a viral infection (Reder & Feng). IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn et al.). IFN-β is a first-line treatment for multiple sclerosis. It suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27. IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue & Shinohara). Out of the two variants of IFN-β (IFN-β1 and IFN-β3), this product is the IFN-β1 form.
Subtype:
Cytokines
Alternative Names:
B cell interferon, Fibroblast interferon, IFNB1, Leukocyte interferon, Type I interferon
Cell Type:
B Cells; NK Cells; T Cells; Cancer Cells and Cell Lines
Species:
Human
Area of Interest:
Immunology; Cancer Research
Molecular Weight:
20 kDa
Purity:
≥ 95%

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(1)

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Data and Publications

Data

(A) The biological activity of Human Recombinant IFN-beta was tested by its ability to inhibit the proliferation of TF-1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.1 ng/mL. (B) 2 μg of Human Recombinant IFN-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

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