Human Recombinant IFN-beta (CHO-expressed)

Interferon-beta

Human Recombinant IFN-beta (CHO-expressed)

Interferon-beta

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Interferon-beta
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Overview

Use Interferon beta (IFN-β) to modulate the activity of genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn et al. Nat Rev Immunol, 2006). IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway. It is predominantly produced by fibroblasts, with smaller amounts from plasmocytoid dendritic cells. Macrophages and endothelial cells secrete IFN-β in response to viral infection (Reder & Feng. Front Immunol, 2013). IFN-β suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27, and is a first-line treatment for multiple sclerosis. IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue & Shinohara. Immunology, 2013). Of the two IFN-β variants (IFN-β1 and IFN-β3), this product is the IFN-β1 form.
Subtype
Cytokines
Alternative Names
B cell interferon, Fibroblast interferon, IFNB1, Leukocyte interferon, Type I interferon
Cell Type
B Cells, Cancer Cells and Cell Lines, NK Cells, T Cells
Species
Human
Area of Interest
Cancer, Immunology
Purity
≥ 92%

Data Figures

Figure 1. Biological Activity and Molecular Mass of Human Recombinant IFN-beta (CHO-expressed)

(A) The biological activity of Human Recombinant IFN-beta (CHO-expressed) was tested in an antiviral assay using WISH cells infected with vesicular stomatitis virus. The EC50 in the above example is ≤ 20 pg/mL. (B) Human Recombinant IFN-beta (CHO-expressed) was resolved with SDS-PAGE under reducing conditions. Human Recombinant G-CSF has a predicted molecular mass of 20 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-1721, 100-1720
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1721
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-1720
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.