The 192-IgG (MC192) antibody clone reacts with CD271 (p75NTR), a 75 kDa type I transmembrane protein. The p75 neurotrophin receptor (p75NTR) is also known as the low-affinity NGF receptor (LNGFR) or CD271. This antibody is useful for the detection of all cells expressing p75NTR on their surface, such as motor neurons in spinal cord, cholinergic basal forebrain neurons, activated Schwann cells, olfactory ensheathing glial cells, and numerous cell lines. This antibody reacts with the extracellular domain of the neurotrophin receptor p75NTR from rat but not other species.
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