Tyrosine kinase inhibitor; Inhibits EGFR, HER2, JAK2, JAK3 and STAT5a/b
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· Induces differentiation of mouse (OG2) embryonic stem cells, with LIF and BMP4 (Chen et al.).
· Blocks growth of acute lymphoblastic leukemia pre-B cells by inducing programmed cell death, via inhibition of JAK2 (Meydan et al.).
· Inhibits proliferation of cervical carcinoma cell lines (Soto-Cruz et al.).
· Inhibits STAT3 phosphorylation and induced translocation of beta-catenin to the cytoplasm in the colorectal cell line SW480 (Kawada et al.).
· Induces S phase arrest of GL15 glioblastoma cells via JAK2 inhibition (Sciaccaluga et al.).
· Inhibits EGF-dependant proliferation of NIH3T3 cell lines (Gazit et al.).
· Blocks IL-2 induced thymidine incorporation in T-cell lines (Wang et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
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Resources and Publications
Educational Materials (2)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.