Anti-Mouse CD48 (SLAMF2) Antibody, Clone HM48-1

Hamster (Armenian) monoclonal IgG1 antibody against mouse CD48 (SLAMF2)

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Hamster (Armenian) monoclonal IgG1 antibody against mouse CD48 (SLAMF2)
From: 115 USD

Overview

The HM48-1 antibody reacts with mouse CD48, a 45 kDa GPI-anchored glycoprotein and a member of the signaling lymphocyte activation molecule (SLAM) family and Ig superfamily. SLAM family members play a role in multiple aspects of immune function including costimulation, cytotoxicity, and cytokine production. CD48 also plays a role in cell adhesion and T cell activation. In mice, CD48 is thought to be present on nearly all hematopoietic cells except neutrophils and ESLAM cells (CD45+EPCR+CD48-CD150+ hematopoietic stem cells with long-term self-renewal capacity). Ligands for CD48 include CD2 and CD244, binding of which helps to promote interactions between immune cells. HM48-1 is reported to be capable of blocking CD48:CD2 and CD48:CD244 interactions in vitro and in vivo. HM48-1 is also reported to inhibit the proliferative response of spleen cells to mitogens, inhibit CTL activity, and enhance the survival of cardiac allografts.
Subtype:
Primary Antibodies
Target Antigen:
CD48 (SLAMF2)
Reactive Species:
Mouse
Conjugation:
APC
Host Species:
Hamster
Cell Type:
B Cells; Hematopoietic Stem and Progenitor Cells; Monocytes; T Cells; Macrophages
Application:
Flow Cytometry
Area of Interest:
Immunology; Stem Cell Biology

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This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) Primary human airway epithelial cells were cultured in PneumaCult™-ALI Medium (Catalog #05001) at the air-liquid interface, then cryo-sectioned and labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, followed by a goat anti-rabbit IgG antibody, Alexa Fluor® 594 (red), and an anti-human NGF Receptor/p75NTR (CD271) antibody, followed by a donkey anti-mouse IgG antibody, Alexa Fluor® 488 (green). (B) Flow cytometry analysis of human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, followed by an anti-mouse IgG1 antibody, PE and anti-human CD3 antibody, Clone HIT3a, Pacific Blue™. (C) Flow cytometry analysis of human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21 (Catalog #60070), followed by an anti-mouse IgG1 antibody, PE, and anti-human CD3 antibody, clone HIT3a, Pacific Blue™.

(A) Flow cytometry analysis of human airway epithelial cells cultured in PneumaCult™-ALI Medium (Catalog #05001) at the air-liquid interface. Cells were enzymatically dissociated and labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, PE (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE (Catalog #60070PE, solid line histogram). (C) Flow cytometry analysis human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Anti-Human MUC1 (CD227) Antibody, Clone 16A, PE and anti-human CD3 antibody, clone HIT3a, Pacific Blue™. (D) Flow cytometry analysis of PHA-activated human peripheral blood lymphocytes following stimulation with PHA for 3 days. Cells were labeled with Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, PE, and anti-human CD3 antibody, clone HIT3a, Pacific Blue™.

Flow cytometry analysis of C57BL/6 mouse splenocytes labeled with Anti-Mouse CD48 (SLAMF2) Antibody, Clone HM48-1, APC (filled histogram) or an Armenian hamster IgG isotype control antibody, APC (solid line histogram).

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.