Human Recombinant IFN-beta

Interferon-beta

Human Recombinant IFN-beta

Interferon-beta

From: 78 USD
Catalog #
78113_C
Interferon-beta

Overview

Interferon beta (IFN-β), also known as type I interferon, is produced by fibroblasts, and in smaller amounts by plasmocytoid dendritic cells. Macrophages and endothelial cells secrete IFN-β in response to a viral infection (Reder & Feng). IFN-β binds to a receptor complex composed of IFNAR1 and IFNAR2, and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control dendritic cell activation, T cell survival, NK cell activation, chemokine expression, lymph node retention, and antiproliferative and antiviral effects (Dunn et al.). IFN-β is a first-line treatment for multiple sclerosis. It suppresses Th17 cells by affecting expression of IL-4, IL-10, and IL-27. IFN-β was also shown to expand regulatory T cells and limit T cell trafficking to the central nervous system (Inoue & Shinohara). Out of the two variants of IFN-β (IFN-β1 and IFN-β3), this product is the IFN-β1 form.
Subtype
Cytokines
Alternative Names
B cell interferon, Fibroblast interferon, IFNB1, Leukocyte interferon, Type I interferon
Cell Type
B Cells, Cancer Cells and Cell Lines, NK Cells, T Cells
Species
Human
Area of Interest
Cancer, Immunology
Molecular Weight
20 kDa
Purity
≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IFN-beta was tested by its ability to inhibit the proliferation of TF-1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 0.1 ng/mL. (B) 2 μg of Human Recombinant IFN-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
78113, 78113.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
78113, 78113.1
Lot #
All
Language
English

Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Resources and Publications

Educational Materials (1)

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