(De Brabander et al.). Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics, impairing formation of the metaphase spindles during the cell division cycle. This prevents mitosis by inducing a G2/M-phase arrest and induces apoptosis in tumor cells (Jordan et al.).
· Synchronizes human pluripotent stem cells (hPSCs) in the G2/M cell cycle phase, thereby increasing the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Lin et al.; Yang et al.).
· Induces apoptosis in leukemic cells without harming T cells and/or mesenchymal stromal cells that were recovered from the same patients (Frezzato et al.).
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.