FK506
Calcineurin/NFAT pathway inhibitor; Binds FKBP-12
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FK506 -
FK506 -
Label for FK506 -
Label for FK506
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Overview
FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.). It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
Alternative Names:
Tacrolimus
CAS Number:
104987-11-3
Chemical Formula:
C₄₄H₆₉NO₁₂
Molecular Weight:
804.0 g/mol
Purity:
≥ 99%
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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.