FK506
Calcineurin/NFAT pathway inhibitor; Binds FKBP-12
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FK506 -
FK506 -
Label for FK506 -
Label for FK506
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Overview
FK506 is a macrolide antibiotic with potent immunosuppressive properties (Thomson et al.). It inhibits the calcineurin/NFAT pathway (Martinez-Martinez & Redondo) and binds with high affinity to FK506 binding protein 12 (FKBP-12) (Thomson et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
MAINTENANCE AND SELF-RENEWAL
· Promotes the self-renewal of mouse embryonic stem cells independent of leukemia inhibitory factor (LIF), and attenuates differentiation following LIF withdrawal (Li et al.).
· In combination with 1-Azakenpaullone (Catalog #74252) and ID-8 (Catalog #72502), enhances the expansion rates of several human pluripotent stem cell lines (Yasuda et al.).
IMMUNOLOGY
· Inhibits pro-inflammatory cytokine production by activated T cells (Sakuma et al.).
Alternative Names:
Tacrolimus
CAS Number:
104987-11-3
Chemical Formula:
C₄₄H₆₉NO₁₂
Molecular Weight:
804.0 g/mol
Purity:
≥ 99%
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