Activin/NODAL/TGF-β pathway inhibitor; Inhibits CK1, ALK5 and p38 MAPK
· Along with forskolin (Catalog #72112) and 2-methyl-5-hydroxytryptamine, reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).
· Reprograms mouse somatic cells into pluripotent cells by acting as a chemical substitute for OCT4 (Hou et al.).
· Induces apoptosis of multiple myeloma cell lines (Hu et al.).
· Exhibits anti-leukemic activity by selectively killing leukemia stem cells over normal hematopoietic stem and progenitor cells (Järås et al.).
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