Anti-SHIP Antibody, Polyclonal
Rabbit polyclonal antibody against mouse SHIP
Overview
SH2-containing inositol phosphatase (SHIP) is a 145 kDa hematopoietic-restricted protein that becomes tyrosine-phosphorylated and associated with the adaptor protein, Shc, following cytokine, growth factor, chemokine, and immunoreceptor stimulation. SHIP also hydrolyzes the critical phosphatidylinositol (PI)-3-kinase (PI3K)-generated second messenger, PI-3,4,5-P3 (PIP3), to PI-3,4-P2 1,2 and therefore acts as an important negative regulator of the PI3K pathway. This antibody reacts with mouse full-length SHIP protein, 145 kDa, as well as the C-terminal truncated 135, 125, and 110 kDa forms.
Subtype
Primary Antibodies
Target Antigen
SHIP
Alternative Names
Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1; p150Ship; SHIP1; SHIP-1; s-SHIP; SIP-145
Reactive Species
Human, Mouse
Conjugation
Unconjugated
Host Species
Rabbit
Cell Type
Granulocytes and Subsets, Lymphocytes, Myeloid Cells
Species
Human, Mouse
Application
Immunoblotting, Immunoprecipitation
Area of Interest
Immunology
Clone
Not applicable
Gene ID
16331
Isotype
Not applicable
Related Products
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
Anti-SHIP Antibody, Polyclonal
|
Catalog #
60141 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
Anti-SHIP Antibody, Polyclonal
|
Catalog #
60141 |
Lot #
All |
Language
English |
Educational Materials (2)
Brochure
Reliable Antibodies for Your Research
Wallchart
Human Immune Cytokines
Data and Publications
Data
Western blot analysis of mouse bone marrow derived mast cells (BMMCs) from normal (+/+) and SHIP knockout (-/-) mice with Anti-SHIP Antibody, Polyclonal (1:4000 dilution). SHIP has a predicted molecular mass of 145 kDa.
Quality Statement:
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