HGF pathway inhibitor; Inhibits MET
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· Induces apoptosis of human myeloma CD138+ plasma cells in vitro, and demonstrates efficacy in a mouse xenograft model of myeloma (Zaman et al.).
· Inhibits metastatic growth of breast cancer cells in bone and reduces tumor-induced osteolysis, in a mouse xenograft model (Previdi et al.).
· Perturbs microtubule dynamics, induces G2/M arrest, and promotes apoptosis independently of c-MET inhibition in a variety of cancer cell lines (Basilico et al.).
Protocols and Documentation
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Resources and Publications
Educational Materials (2)
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