Tivantinib
HGF pathway inhibitor; Inhibits MET
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In-lab demonstration
Overview
CANCER RESEARCH
· Induces apoptosis of human myeloma CD138+ plasma cells in vitro, and demonstrates efficacy in a mouse xenograft model of myeloma (Zaman et al.).
· Inhibits metastatic growth of breast cancer cells in bone and reduces tumor-induced osteolysis, in a mouse xenograft model (Previdi et al.).
· Perturbs microtubule dynamics, induces G2/M arrest, and promotes apoptosis independently of c-MET inhibition in a variety of cancer cell lines (Basilico et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Resources and Publications
Educational Materials (2)
Publications (7)
Abstract
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Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.