Human pluripotent stem cell (hPSC)-derived neural organoids offer unique opportunities to study the human brain using physiologically relevant and complex 3D models. Neural organoid differentiation strategies may be broadly classified into two major types of methodologies–patterned and unpatterned. Depending on the desired downstream application or readout, one (or both) of these options may provide a powerful tool to help you address exciting new research questions.
Patterned Neural Organoids
Patterned neural organoid strategies rely on directed differentiation using small molecule patterning factors to generate specific brain regions of interest.
Key Features & Applications:
Highly reproducible and homogeneous structural morphology for greater study sensitivity
Easily scalable with AggreWell™ for high-throughput applications to generate hundreds of organoids in a single batch
Studying inter-organoid interactions by generating assembloids1,2 (modular combinations of different patterned organoids into one system)
Co-culturing with hPSC-derived microglia to model neuroinflammation