Modeling Human Gastrointestinal Development and Disease Using Pluripotent Stem Cells

Organoids are three-dimensional (3D) cell cultures containing a self-renewing stem cell population which differentiates into multiple, organ-specific cell types demonstrating key features of the represented organ. Advancements in organoid culture, such as the co-culture of different tissue types, further increases their utility as models of the in vivo organ and provides researchers a convenient platform to complement existing 2D culture and animal models. In this webinar, Dr. James Wells discusses the generation of human intestinal organoids containing a functional enteric nervous system, the differentiation of gastric organoids, and the application of these systems to examine intestinal motility disorders and gastric infection with Helicobacter pylori.