ISSCR Innovation Showcase: Differentiating Immune Cells from Human Pluripotent Stem Cells in Feeder- and Serum-Free Cultures

In this Innovation Showcase talk from ISSCR 2020 Virtual, Dr. Nooshin Tabatabaei-Zavareh demonstrates how to differentiate immune cells from human pluripotent stem cells (hPSCs) in feeder- and serum-free cultures.

hPSCs may provide an unlimited source of immune cells for disease modeling, gene editing, and cell therapy development applications. Differentiation of hPSCs into immune cells is challenging and often involves the use of serum and feeder cells, which can be difficult to standardize. Dr. Tabatabaei-Zavareh reviews the development of multi-step feeder- and serum-free culture systems for differentiating hPSCs into T cells, NK cells, or monocytes, which are similar to their counterparts in peripheral blood. Her results show that hPSCs can be differentiated under feeder- and serum-free conditions into immune cells for basic and translational research.
Publish Date: August 17, 2020 Views: 0