Modeling Alzheimer's risk using human TREM2-knockout microglia
Amanda McQuade from Dr. Mathew Blurton-Jones’s lab discusses her protocol for differentiating microglia from induced pluripotent stem cells (iPSCs) and the use of these microglia in vivo and in vitro to uncover the mechanisms of immune activation and neurodegeneration in Alzheimer’s disease.
Amanda McQuade from Dr. Mathew Blurton-Jones’s lab discusses her protocol for differentiating microglia from induced pluripotent stem cells (iPSCs) and the use of these microglia in vivo and in vitro to uncover the mechanisms of immune activation and neurodegeneration in Alzheimer’s disease. Based on the 2020 Nature Communications paper "Gene Expression and Functional Deficits Underlie TREM2-Knockout Microglia Responses in Human Models of Alzheimer’s Disease"
Publish Date:
February 11, 2021
Request Pricing
Thank you for your interest in this product. Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.
Related Multimedia
-
How to Count hPSC Aggregates to Determine Plating Density for Maintenance and Differentiation
Publish Date: October 14, 2019 -
STEMCELL Journal Club: Patient-Derived Alzheimer’s Disease Modeling
Publish Date: May 25, 2020 -
Engineering the Hematopoietic System to Treat Non-Hematological Disorders
Publish Date: February 03, 2020
Explore Our Products
-
Defined supplement for single-cell cloning of human ES and iPS cells -
STEMdiff™ Microglia Differentiation Kit
Differentiation kit for the generation of microglia precursors from human ES and iPS cell-derived hematopoietic progenitor cells -
Feeder-free, animal component-free culture medium for maintenance of human ES and iPS cells -
For differentiation of human ES or iPS cells into hematopoietic progenitor cells
