Human iPSC BBB Models for Studying Immune Cell Interactions
There are several protocols available to differentiate hiPSCs into brain microvascular endothelial cell (BMEC)-like cells. It is therefore relevant that researchers choose the appropriate protocol for their research question.
The speakers of this webinar have established a novel protocol, the Extended Endothelial Cell culture Method (EECM), allowing to differentiate hiPSCs into BMECs resembling primary human BMECs with respect to barrier properties and endothelial adhesion molecule expression. They will furthermore introduce EECM-BMECs as a suitable tool to study BBB dysfunction in multiple sclerosis.
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