Resources for T Cell Therapy Research and Development
Welcome to our dedicated portal for translational T cell research and T cell therapy development! As a scientist in the cell therapy field, you're at the forefront of developing groundbreaking therapies. Whether you're conducting translational T cell research or looking to manufacture T cell therapies, our comprehensive resources are designed to support and enhance your research endeavors. Dive in to discover tools and technologies for your T cell workflow.
Advancing T Cell Therapies: Insights from the Translational T Cell Talks
On June 11, 2024, STEMCELL Technologies hosted the half-day virtual event “Translational T Cell Talks: Scaling for the Future” in collaboration with Scientist.com. The presentations from distinguished scientists and industry leaders, provided insights into the latest developments in translational T cell research and CAR T cell innovations, and concluded with a discussion on improving collaboration between industry and academia.
T Cell Webinars
How to Create CRISPR-Edited T Cells
In this webinar, Artisan Bio’s Steven Loo-Yong-Kee details the company’s approach to building safe, optimized CRISPR guides. Learn about Artisan Bio's STAR-CRISPR system for improving the specificity and efficiency of gene editing for cell therapies.
Accelerating T Cell Therapy Research
Learn how to optimize your T cell workflow and advance your T cell therapy research. Dr. Balani, Product Manager, STEMCELL Technologies and Dr. Zhang, Senior Product Manager, Precision NanoSystems discuss tools and technologies for T cell research and dive into how lipid nanoparticles can enable cell therapy researchers to establish a clinically relevant method for ex vivo gene delivery.
Assessing Antigen-Specific T Cell Functionality with Dendritic Cell/CD8+ T Cell Co-Culture
Learn how to use DC/CD8+ T cell co-culture to study the antigen-specific responses of CD8+ T cells, including their activation, proliferation, cytokine production, and cytotoxic activity.
Cancer Cells Impair T Cell Metabolism
Discover how tumor cells disrupt methionine metabolism in CD8+ T cells with this webinar presented by Dr. Yingjie Bian. Dr. Bian focuses on nutrient competition in the tumor microenvironment and how cancer cells with high expression of the methionine transporter, SLC43A2, cause epigenetic changes that reduce T cell-mediated anti-tumor immunity.
Immunometabolism: Metabolic Control of T Cell Differentiation and Function
Dr. Corrado provides an overview on the role of mitochondrial metabolism for CD8+ T cells and presents his recent paper in Cell Metabolism on how cardiolipin synthesis and remodeling is required for CD8+ T cell immunity.
Efficient Delivery of the CRISPR-Cas System to Primary Cells by Peptide-Assisted Genome Editing
In this webinar, Dr. Zhang will discuss his recent work published in Nature Biotechnology, which describes an engineered peptide-assisted genome editing CRISPR-Cas system for efficient editing of primary cells with minimal toxicity.
Differentiating Immune Cells from Human Pluripotent Stem Cells in Feeder- and Serum-Free Cultures
Drs. Tabatabaei-Zavareh and Brauer introduce tools that offer optimal conditions for generating immune cells from alternative cell sources, including cord blood and pluripotent stem cells.
Online Immunology Journal Club: Expanding the Therapeutic Tool Kit for CAR T Cells
In this second episode of our Online Immunology Journal Club, Principal Scientist Dr. Siatskas reviews publications within the area of CAR T cell therapy.
Online Immunology Journal Club: Human In Vitro T Cell Development
In this first episode of our Online Immunology Journal Club, Senior Scientist Dr. Patrick Brauer reviews recent publications within the area of human in vitro T cell development.
CD8+ TILs and Breast Cancer: Identifying New Opportunities for Immunotherapeutic Intervention
Dr. Egelston discusses recent efforts to isolate and characterize phenotypically and functionally exhausted CD8+ tumor-infiltrating lymphocytes from a subset of breast tumors.
From hPSCs to Immune Cells: Immune Cell Generation from Human Pluripotent Stem Cells in Feeder- and Serum-Free Cultures
As part of a London Stem Cell Network workshop, co-organized by STEMCELL, Tim Le Fevre discusses applications and advantages of human pluripotent stem cell (hPSC)-derived immune cells for cell therapy research.
Using Stable Isotope Tracing to Study CD8+ Immune Cell Dynamics In Vivo
Metabolic reprogramming is an essential part of the T cell activation program. This webinar provides insights into the metabolism of physiologically activated CD8+ T cells and a new method to study T cell nutrient utilization in vivo.
Optimized Workflows for High-Efficiency Genome Editing in Stem and Primary Cell Types
In this webinar, our in-house expert, Dr. Ashley Watson, discusses optimized workflows for CRISPR-Cas9 genome editing in human pluripotent stem cells and primary T cells.
Lost in Translation - Moving Your Research to Clinical Trials
In this webinar, Dr. Adrian Gee from the Baylor College of Medicine and Dr. David McKenna from the University of Minnesota discuss the process of translating cell therapy research to the clinic.
Qualification of Ancillary/Raw Materials for Clinical Use
This presentation is a step-by-step guide to qualify ancillary materials for clinical use. It focuses on the path to qualification, region-specific regulations and guidelines, common industry issues, and case studies.
Other Resources
