Nocodazole

Microtubule polymerization inhibitor; Inhibits beta-tubulin
Catalog #
74072_C
Microtubule polymerization inhibitor; Inhibits beta-tubulin
From: 104 USD

Overview

Nocodazole is an anti-mitotic agent that reversibly interferes with the polymerization of microtubules
(De Brabander et al.). Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics, impairing formation of the metaphase spindles during the cell division cycle. This prevents mitosis by inducing a G2/M-phase arrest and induces apoptosis in tumor cells (Jordan et al.).


GENOME EDITING
· Synchronizes human pluripotent stem cells (hPSCs) in the G2/M cell cycle phase, thereby increasing the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Lin et al.; Yang et al.).

CANCER RESEARCH
· Induces apoptosis in leukemic cells without harming T cells and/or mesenchymal stromal cells that were recovered from the same patients (Frezzato et al.).
Alternative Names
NSC 238159; Oncodazole; R 17934
Cell Type
Cancer Cells and Cell Lines, Leukemia/Lymphoma Cells, Pluripotent Stem Cells
Species
Human, Mouse, Rat, Non-Human Primate, Other
Application
Genome Editing
Area of Interest
Cancer, Stem Cell Biology
CAS Number
31430-18-9
Chemical Formula
C₁₄H₁₁N₃O₃S
Molecular Weight
301.3 g/mol
Purity
≥ 98%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Nocodazole
Catalog #
74072, 74074
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Nocodazole
Catalog #
74072, 74074
Lot #
All
Language
English

Educational Materials (3)

Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Mini Review
Small Molecules

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Research Area
Workflow Stages
Workflow Stages for Genome Editing

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