Nocodazole
Microtubule polymerization inhibitor; Inhibits beta-tubulin
Request Pricing
Thank you for your interest in this product. Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):
Estimated delivery time for your area
Product sample or exclusive offer
In-lab demonstration
Overview
(De Brabander et al.). Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics, impairing formation of the metaphase spindles during the cell division cycle. This prevents mitosis by inducing a G2/M-phase arrest and induces apoptosis in tumor cells (Jordan et al.).
GENOME EDITING
· Synchronizes human pluripotent stem cells (hPSCs) in the G2/M cell cycle phase, thereby increasing the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Lin et al.; Yang et al.).
CANCER RESEARCH
· Induces apoptosis in leukemic cells without harming T cells and/or mesenchymal stromal cells that were recovered from the same patients (Frezzato et al.).
Protocols and Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Applications
This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.
Resources and Publications
Educational Materials (3)
Related Products
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
