Nocodazole

Microtubule polymerization inhibitor; Inhibits beta-tubulin

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Microtubule polymerization inhibitor; Inhibits beta-tubulin
From: 94 USD

Overview

Nocodazole is an anti-mitotic agent that reversibly interferes with the polymerization of microtubules
(De Brabander et al.). Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics, impairing formation of the metaphase spindles during the cell division cycle. This prevents mitosis by inducing a G2/M-phase arrest and induces apoptosis in tumor cells (Jordan et al.).


GENOME EDITING
· Synchronizes human pluripotent stem cells (hPSCs) in the G2/M cell cycle phase, thereby increasing the efficiency of homology-directed repair (HDR) in CRISPR-Cas9 genome editing (Lin et al.; Yang et al.).

CANCER RESEARCH
· Induces apoptosis in leukemic cells without harming T cells and/or mesenchymal stromal cells that were recovered from the same patients (Frezzato et al.).
Alternative Names:
NSC 238159; Oncodazole; R 17934
CAS Number:
31430-18-9
Chemical Formula:
C₁₄H₁₁N₃O₃S
Molecular Weight:
301.3 g/mol
Purity:
≥ 98%

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.