Anti-Human CD38 Antibody, Clone AT-1

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD38

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Anti-Human CD38 Antibody, Clone AT-1, FITC

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD38, FITC-conjugated

100 Tests
Catalog #60131FI
201 USD

Overview

The AT-1 antibody reacts with CD38, an ~45 kDa type II integral membrane glycoprotein that is part of the ADP-ribosyl cyclase family. CD38 is widely expressed at variable levels on hematopoietic cells including early B and T cell lineages, activated B and T cells, NK cells, monocytes, and dendritic cells. It is strongly expressed in plasma cells. CD38 is also expressed in some non-hematopoietic tissues such as brain, kidney, muscle, and pancreas. CD38 is an ectoenzyme that acts as both an ADP-ribosyl cyclase and ADP-ribose (ADPR) hydrolase for the synthesis and hydrolysis of cyclic ADPR (cADPR) and NAADP. cADPR acts as a second messenger for intracellular calcium mobilization to facilitate glucose-induced insulin secretion. It has been shown that the AT-1 antibody mutually competes for binding with OKT10 and SUN-4B7, and all three clones only bind the native (not reduced) form of CD38.
Subtype:
Primary Antibodies
Target Antigen:
CD38
Alternative Names:
ADP-ribosyl cyclase, cADPR, Cyclic ADP-ribose hydrolase, T10
Reactive Species:
Human; Cynomolgus; Rhesus
Conjugation:
FITC
Host Species:
Mouse
Cell Type:
B Cells; Plasma Cells; Hematopoietic Stem and Progenitor Cells
Application:
Cell Isolation; Flow Cytometry
Area of Interest:
Immunology; Stem Cell Biology
Clone:
AT-1
Gene ID:
952
Isotype:
IgG1, kappa

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