Anti-Human CD38 Antibody, Clone AT-1

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD38
Anti-Human CD38 Antibody, Clone AT-1, FITC

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD38, FITC-conjugated

100 Tests
Catalog # 60131FI
228 USD

Overview

The AT-1 antibody reacts with CD38, an ~45 kDa type II integral membrane glycoprotein that is part of the ADP-ribosyl cyclase family. CD38 is widely expressed at variable levels on hematopoietic cells including early B and T cell lineages, activated B and T cells, NK cells, monocytes, and dendritic cells. It is strongly expressed in plasma cells. CD38 is also expressed in some non-hematopoietic tissues such as brain, kidney, muscle, and pancreas. CD38 is an ectoenzyme that acts as both an ADP-ribosyl cyclase and ADP-ribose (ADPR) hydrolase for the synthesis and hydrolysis of cyclic ADPR (cADPR) and NAADP. cADPR acts as a second messenger for intracellular calcium mobilization to facilitate glucose-induced insulin secretion. It has been shown that the AT-1 antibody mutually competes for binding with OKT10 and SUN-4B7, and all three clones only bind the native (not reduced) form of CD38.
Subtype
Primary Antibodies
Target Antigen
CD38
Reactive Species
Cynomolgus, Rhesus, Human
Conjugation
FITC
Host Species
Mouse
Cell Type
B Cells, Hematopoietic Stem and Progenitor Cells, Plasma
Species
Human
Application
Cell Isolation, Flow Cytometry
Area of Interest
Immunology, Stem Cell Biology

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD38 Antibody, Clone AT-1, FITC
Catalog #
60131FI
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD38 Antibody, Clone AT-1, FITC
Catalog #
60131FI
Lot #
All
Language
English

Educational Materials (1)

Wallchart
Human Immune Cytokines

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