Anti-Human CD25 Antibody, Clone 2A3

Mouse monoclonal IgG1 antibody against human, cynomolgus CD25

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Anti-Human CD25 Antibody, Clone 2A3, PE

Mouse monoclonal IgG1 antibody against human, cynomolgus CD25, PE-conjugated

50 Tests
Catalog #60153PE
611 USD

Overview

The 2A3 antibody reacts with human CD25, a 55 kDa type I integral transmembrane glycoprotein also known as low-affinity interleukin 2 receptor alpha chain (IL-2Rα) or Tac antigen. CD25 is present on activated T and B cells, monocytes, macrophages, and regulatory T cells. CD25 has role in T lymphocyte activations and identification of T cell subsets in viral infections like HIV and HTLV. CD25 associates with IL-2 receptor β (CD122) and common γ (CD132) chains to form a high affinity IL-2R complex. The 2A3 antibody binds to an epitope on p55 at or near the IL-2 binding site and prevents high-affinity IL-2 binding to T lymphocytes. Daclizumab, a therapeutic humanised monoclonal antibody, blocks the binding of 2A3 antibody.
Subtype:
Primary Antibodies
Target Antigen:
CD25
Alternative Names:
IL-R2α, Interleukin 2 receptor alpha, Low affinity IL-2R, p55, Tac
Reactive Species:
Cynomolgus; Human
Conjugation:
PE
Host Species:
Mouse
Cell Type:
T Cells; T Cells, Regulatory
Application:
Cell Isolation; Flow Cytometry
Area of Interest:
Immunology; T Cell Engineering
Clone:
2A3
Gene ID:
100
Isotype:
IgG1, kappa

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STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.