Mouse Recombinant IFN-gamma

Interferon-gamma

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Interferon-gamma
From: 82 USD

Overview

Interferon-gamma (IFN-γ), also known as type II interferon, is produced by T and NK cells, and in smaller amounts by dendritic cells and macrophages. IFN-γ is controlled by cytokines such as IL-12 and IL-18 secreted in response to infection (Schroder et al.). IFN-γ binds to a receptor complex and initiates signal transduction via the JAK/STAT pathway; this culminates in the transcription and activation of many genes that control a diverse array of immunological functions (De Weerd and Nguyen; Krause et al.). IFN-γ stimulates the antimicrobial and anti-tumor activity of macrophages, NK cells, and neutrophils (Billiau & Matthys) by promoting the activation of microbial effector functions such as production of reactive oxygen species, NO intermediates, complement, etc. (Schroder et al.). IFN-γ enhances MHC class I and II expression in dendritic cells and mononuclear phagocytes, as well as the production of IL-12 by dendritic cells. In B cells, IFN-γ stimulates survival and growth in both mouse and human cells, and redirects B cells from proliferation towards differentiation. IFN-γ favors the development of Th1 vs Th2 cells and stimulates monocyte differentiation and function (Schroder et al.).
Alternative Names:
Interferon gamma, Type II interferon
Cell Type:
B Cells; Hematopoietic Stem and Progenitor Cells; Intestinal Cells; Mesenchymal Stem and Progenitor Cells; T Cells
Species:
Mouse
Area of Interest:
Epithelial Cell Biology; Immunology; Stem Cell Biology
Molecular Weight:
15.7 kDa
Purity:
≥ 95%

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Educational Materials

(3)

Data and Publications

Data

(A) The biological activity of Mouse Recombinant IFN-gamma was measured with L929 cells exposed to the encephalomyocarditis (EMC) virus in a cytopathic effect (CPE) assay. The specific activity in the above example is 1.25 x 10^6 units/mg.
(B) 1 μg of Mouse Recombinant IFN-gamma was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Mouse Recombinant IFN-gamma has a predicted molecular mass of 15.7 kDa.

PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.