(+)-MK-801 (Hydrogen Maleate)

NMDA antagonist

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(+)-MK-801 (Hydrogen Maleate)

NMDA antagonist

From: 93 USD

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10 mg

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NMDA antagonist

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Overview

(+)-MK-801 is a neuroprotective agent and a noncompetitive N-methyl-D-aspartate (NMDA) antagonist (Ki = 30.5 nM; Foster et al.; Wong et al.). NMDA receptor is a calcium-permeable ion channel found in neurons and regulated by its ligands glutamate and glycine (Song et al.). NMDA receptor signaling is involved with plasticity, cell survival, and cell death. Hyperactivity of these receptors can result in neuron loss and may contribute to neurodegenerative diseases (Parsons & Raymond; Song et al.).

DISEASE MODELING
· Protects against neuron loss in rat striatum and hippocampus (Wong et al.).

Dizocilpine

Neurons

Disease Modeling, Neuroscience

77086-22-7

C16H15N • C4H4O4

337.4 g/mol

≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

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Document Type

Product Information Sheet

Product Name

(+)-MK-801 (Hydrogen Maleate)

Catalog #

100-0886

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All

Language

English

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Safety Data Sheet

Product Name

(+)-MK-801 (Hydrogen Maleate)

Catalog #

100-0886

Lot #

All

Language

English

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(+)-MK-801 (Hydrogen Maleate)

NMDA antagonist

(+)-MK-801 (Hydrogen Maleate)

NMDA antagonist

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Overview

Protocols and Documentation

Resources and Publications

Educational Materials (3)

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