Memantine (Hydrochloride)

NMDA receptor antagonist

Memantine (Hydrochloride)

NMDA receptor antagonist

From: 69 USD
Catalog #
100-0894_C
NMDA receptor antagonist

Overview

Memantine is a N-methyl-D-aspartate (NMDA) receptor antagonist that stimulates the production of dopamine in the brain (Parsons et al.). NMDA receptor is a calcium-permeable ion channel found in neurons and regulated by its ligands glutamate and glycine (Song et al.). NMDA receptor signaling is involved with plasticity, cell survival, and cell death. Hyperactivity of these receptors can result in neuron loss and may contribute to neurodegenerative diseases (Parsons & Raymond; Song et al.). Memantine is used to treat patients with Parkinson's disease and Alzheimer's disease (Meisner et al.; Parsons et al.).

DISEASE MODELING
· Upregulates the expression of brain-derived neurotrophic factor (BDNF) and prevents the onset of dopamine deficiency in macaques infected with simian immunodeficiency virus (SIV; Meisner et al.).
Alternative Names
Akatinol; Axura; Ebix; Namenda; NSC 102290; SUN Y7017
Area of Interest
Disease Modeling, Neuroscience
CAS Number
41100-52-1
Chemical Formula
C12H21N • HCl
Molecular Weight
215.8
Purity
≥ 98%

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type
Product Name
Catalog #
Lot #
Language
Catalog #
100-0894
Lot #
All
Language
English
Document Type
Safety Data Sheet
Catalog #
100-0894
Lot #
All
Language
English

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