Human Recombinant NGF-beta

Nerve growth factor beta
Catalog #
78092_C
Nerve growth factor beta
From: 153 USD

Overview

Nerve growth factor (NGF)-beta is a prototypical member of the neurotrophin family and has a role in the survival and growth of neural cells, regulating cell growth, promoting differentiation into neurons, and neuron migration. The beta subtype of NGF is biologically active in comparison to the alpha-2 and gamma-2 subtypes. NGF-beta in its secreted form can bind to tyrosine kinase A (TrkA) receptor with high affinity and to p75 (NTR) with low affinity (Levi & Alemà; Sofroniew et al.). NGF has been shown to possess pro-inflammatory and pro-fibrogenic properties (Micera et al.). It has also been shown that overexpression of NGF-beta promotes differentiation of bone marrow mesenchymal stem cells into neurons through regulation of AKT and MAPK pathways (Yuan et al.).
Subtype
Cytokines, Growth Factors
Alternative Names
Beta-nerve growth factor, beta-NGF, nerve growth factor (beta polypeptide)
Cell Type
Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Neurons
Species
Human
Area of Interest
Immunology, Stem Cell Biology
Molecular Weight
13.6 kDa monomer; 27.3 kDa dimer
Purity
≥ 95%

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Human Recombinant NGF-beta
Catalog #
78092, 78092.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Human Recombinant NGF-beta
Catalog #
78092, 78092.1
Lot #
All
Language
English

Educational Materials (3)

Brochure
hPSC-Derived Neural Cell Research
Brochure
Cytokines, Chemokines and Growth Factors
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

(A) The biological activity of Human Recombinant NGF-beta was tested by its ability to promote the proliferation of TF-1 cells grown in GM-CSF free medium. Cell proliferation was measured after 67 hours of culture using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the example above is 0.54 ng/mL. (B) 1 μg of Human Recombinant NGF-beta was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant NGF-beta is a homodimer of 13.6 kDa subunits with a predicted total molecular mass of 27.3 kDa.

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