Human Recombinant IGF-I

Insulin-like growth factor 1

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Insulin-like growth factor 1
From: 82 USD

Overview

Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).
Alternative Names:
IBP1, IGF-IA, IGF-IB, IGF1A, Insulin-like growth factor 1, Mechano growth factor, MGF, Somatomedin C
Cell Type:
Neural Cells, PSC-Derived; Neural Stem and Progenitor Cells; Prostate Cells
Species:
Human
Area of Interest:
Epithelial Cell Biology; Neuroscience; Stem Cell Biology
Molecular Weight:
7.7 kDa
Purity:
≥ 95%

Scientific Resources

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Educational Materials

(2)

Data and Publications

Data

(A) The biological activity of Human Recombinant IGF-I was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 5 ng/mL.
(B) 2 μg of Human Recombinant IGF-I was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IGF-I has a predicted molecular mass of 7.7 kDa.

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