Human Recombinant IGF-I

Insulin-like growth factor 1

Skip to the end of the images gallery

Skip to the beginning of the images gallery

Human Recombinant IGF-I

Insulin-like growth factor 1

From: 85 USD

Size

100 µg 500 µg 1000 µg

Catalog #

(Select a product)

Insulin-like growth factor 1

Quantity

Add to Wish List

Request Pricing

Thank you for your interest in this product. Please provide us with your contact information and your local representative will contact you with a customized quote. Where appropriate, they can also assist you with a(n):

Estimated delivery time for your area

Product sample or exclusive offer

In-lab demonstration

By submitting this form, you are providing your consent to STEMCELL Technologies Canada Inc. and its subsidiaries and affiliates (“STEMCELL”) to collect and use your information, and send you newsletters and emails in accordance with our privacy policy. Please contact us with any questions that you may have. You can unsubscribe or change your email preferences at any time.

Overview

Insulin-like growth factor 1 (IGF-I) is a polypeptide that belongs to the family of insulin-like growth factors that are similar in molecular structure to proinsulin. IGF-I binds to the IGF-I receptor and is a potent activator of the PI3K/AKT pathway and also activates ERK1/2 signaling. IGF-I is required for embryonic development, and it is produced mainly in the liver in response to a hepatocyte growth hormone. In the absence of insulin, IGF-I is necessary for the maintenance of human pluripotent stem cells (Wang et al.). Together with IL-3, IGF-I stimulates differentiation and proliferation of myeloid cells and has been shown to regulate lymphopoiesis by stimulating proliferation and differentiation of T and B cells in lymphoid organs (Heemskerk et al.).

Cytokines, Growth Factors

Neural Cells, PSC-Derived, Neural Stem and Progenitor Cells, Prostate Cells

Human

Epithelial Cell Biology, Neuroscience, Stem Cell Biology

≥ 95%

Data Figures

(A) The biological activity of Human Recombinant IGF-I was tested by its ability to promote the proliferation of FDC-P1 cells. Cell proliferation was measured using a fluorometric assay method. The EC50 is defined as the effective concentration of the growth factor at which cell proliferation is at 50% of maximum. The EC50 in the above example is less than 5 ng/mL.
(B) 2 μg of Human Recombinant IGF-I was resolved with SDS-PAGE under reducing (+) and non-reducing (-) conditions and visualized by Coomassie Blue staining. Human Recombinant IGF-I has a predicted molecular mass of 7.7 kDa.

Protocols and Documentation

Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.

Document Type

Product Name

Catalog #

Lot #

Language

Document Type

Product Information Sheet

Product Name

Human Recombinant IGF-I

Catalog #

78022.2, 78022, 78022.1

Lot #

All

Language

English

Document Type

Safety Data Sheet

Product Name

Human Recombinant IGF-I

Catalog #

78022.2, 78022, 78022.1

Lot #

All

Language

English

Resources and Publications

Related Products

Quality Statement:

STEMCELL TECHNOLOGIES INC.’S QUALITY MANAGEMENT SYSTEM IS CERTIFIED TO ISO 13485. PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED.

Human Recombinant IGF-I

Insulin-like growth factor 1

Human Recombinant IGF-I

Insulin-like growth factor 1

Request Pricing

Overview

Data Figures

Protocols and Documentation

Resources and Publications

Educational Materials (2)

Related Products

Item added to your cart