Tyrosine kinase inhibitor; Inhibits ABL, SRC, LCK and YES
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· Inhibits proliferation in cell lines derived from chronic myeloid leukemia (CML), prostate, breast, and colon tumors (Lombardo et al.).
· Inhibits proliferation of cells with imatinib-resistant BCR-ABL mutations (Shah et al.).
· Inhibits tumor growth and development of lymph node metastases in orthotopic nude mouse models of prostate cancer (Park et al.).
· Induces cell-cycle arrest and apoptosis and decreases growth in thyroid cancer cells (Chan et al.).
· Inhibits production of extracellular matrix proteins in dermal fibroblasts and prevents development of bleomycin-challenge-induced fibrosis in mice (Distler & Distler; Akhmetshina et al.).
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Resources and Publications
Educational Materials (2)
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PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.