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The YE1/32.8.5 antibody reacts with Ly-49A, a member of the C-type lectin family of proteins. Ly-49A is a type II transmembrane protein expressed as a 44 kDa disulfide-linked homodimer on the surface of subsets of natural killer (NK) cells, NK-T cells, and T cells by some mammalian species, but not humans. It functions to inhibit NK cell activation by binding to certain haplotypes of MHC class I molecules on target cells, specifically H-2Dd and H2Dk, which results in phosphorylation of the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic domain and the recruitment of tyrosine phosphatases, such as SHP-1 and SHP-2. While many anti-Ly-49A antibodies are strain-specific, the YE1/32.8.5 antibody reacts with NK cells from all strains of mice tested. This antibody inhibits the binding of Ly-49A to its ligands and reverses the inhibition of NK cytotoxicity mediated by specific MHC class I molecules on target cells. It very weakly cross-reacts with Ly-49D, but the levels of cross-reactivity are deemed too low to affect flow cytometric analysis of NK cells for functional studies of Ly-49A.
Subtype
Primary Antibodies
Target Antigen
Ly-49A
Alternative Names
Killer cell lectin-like receptor subfamily A member 1, Klra1, Lymphocyte antigen 49a, Natural killer cell receptor Ly49A, T lymphocyte antigen A1
Mouse monoclonal IgG2a, kappa isotype control antibody
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Anti-Mouse Ly-49A Antibody, Clone YE1/32.8.5
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
