Anti-Human CD3 Antibody, Clone SK7

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3
Catalog #
60127_C
Mouse monoclonal IgG1 antibody against human, chimpanzee CD3
From: 105 USD

Overview

The SK7 antibody reacts with the ~20 kDa CD3ε subunit of the human T cell receptor (TCR)/CD3 complex, which is expressed on the surface of ~95% of mature T cells and NKT cells, and variably on thymocytes. A majority of T cell neoplasms also express CD3. The CD3 complex, which is assembled from combinations of CD3γ, δ, ε, η and ζ subunits, associates non-covalently with the TCR and is involved in transducing antigen recognition signals into the cytoplasm of T cells and in regulating the cell surface expression of the TCR. Activation of T cells by the TCR involves the cytoplasmic tails of the CD3 subunits, which are structurally related type 1 transmembrane proteins and members of the immunoglobulin superfamily. Mutations in the CD3 subunits have been associated with various immunodeficiency disorders, including severe combined immunodeficiency (SCID).
Subtype
Primary Antibodies
Target Antigen
CD3
Reactive Species
Chimpanzee, Human
Conjugation
FITC
Host Species
Mouse
Cell Type
T Cells
Species
Human, Non-Human Primate
Application
Cell Isolation, Flow Cytometry
Area of Interest
Immunology

Scientific Resources

Product Documentation

Document Type Product Name Catalog # Lot # Language
Document Type
Product Information Sheet
Product Name
Anti-Human CD3 Antibody, Clone SK7, FITC
Catalog #
60127FI, 60127FI.1
Lot #
All
Language
English
Document Type
Safety Data Sheet
Product Name
Anti-Human CD3 Antibody, Clone SK7, FITC
Catalog #
60127FI, 60127FI.1
Lot #
All
Language
English

Educational Materials (2)

Brochure
Reliable Antibodies for Your Research
Wallchart
Human Immune Cytokines

Product Applications

This product is designed for use in the following research area(s) as part of the highlighted workflow stage(s). Explore these workflows to learn more about the other products we offer to support each research area.

Data and Publications

Data

Figure 1. Data for FITC Conjugated

Flow cytometry analysis of human peripheral blood mononuclear cells (PBMCs) labeled with Anti-Human CD3 Antibody, Clone SK7, FITC (filled histogram) or Mouse IgG1, kappa Isotype Control Antibody, Clone MOPC-21, FITC (Catalog #60070FI; solid line histogram).

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