3-Methyladenine
PI3K/AKT pathway inhibitor
Overview
3-Methyladenine has been reported to inhibit autophagy (Seglen & Gordon) by blocking autophagosome formation via the persistent inhibition of class I and transient inhibition of class III phosphoinositide 3-kinase (PI3K; Wu et al.).
METABOLISM
· Inhibits autophagy in isolated rat hepatocytes (Wu et al.).
METABOLISM
· Inhibits autophagy in isolated rat hepatocytes (Wu et al.).
Alternative Names
3-MA; NSC 66389
Cell Type
Cancer Cells and Cell Lines
Species
Human, Mouse, Rat, Non-Human Primate, Other
Area of Interest
Autophagy, Cancer, Metabolism
CAS Number
5142-23-4
Chemical Formula
C₆H₇N₅
Molecular Weight
149.2 g/mol
Purity
≥ 95%
Pathway
PI3K/AKT
Target
PI3K
Related Products
Related Products
Scientific Resources
Product Documentation
| Document Type | Product Name | Catalog # | Lot # | Language |
|---|---|---|---|---|
|
Document Type
Product Information Sheet
|
Product Name
3-Methyladenine
|
Catalog #
74222 |
Lot #
All |
Language
English |
|
Document Type
Safety Data Sheet
|
Product Name
3-Methyladenine
|
Catalog #
74222 |
Lot #
All |
Language
English |
Educational Materials (4)
Protocol
How to Count Cells with a Hemocytometer
Wallchart
Small Molecules, Big Impact in Cancer Research
Wallchart
Small Molecules, Big Impact in Pluripotent Stem Cell Research
Mini Review
Small Molecules
Quality Statement:
PRODUCTS ARE FOR RESEARCH USE ONLY AND NOT INTENDED FOR HUMAN OR ANIMAL DIAGNOSTIC OR THERAPEUTIC USES UNLESS OTHERWISE STATED. FOR ADDITIONAL INFORMATION ON QUALITY AT STEMCELL, REFER TO WWW.STEMCELL.COM/COMPLIANCE.
