3-Methyladenine
PI3K/AKT pathway inhibitor
Overview
3-Methyladenine has been reported to inhibit autophagy (Seglen & Gordon) by blocking autophagosome formation via the persistent inhibition of class I and transient inhibition of class III phosphoinositide 3-kinase (PI3K; Wu et al.).
METABOLISM
· Inhibits autophagy in isolated rat hepatocytes (Wu et al.).
METABOLISM
· Inhibits autophagy in isolated rat hepatocytes (Wu et al.).
Alternative Names
3-MA; NSC 66389
Cell Type
Cancer Cells and Cell Lines
Species
Human, Mouse, Rat, Non-Human Primate, Other
Area of Interest
Autophagy, Cancer, Metabolism
CAS Number
5142-23-4
Chemical Formula
C₆H₇N₅
Molecular Weight
149.2 g/mol
Purity
≥ 95%
Pathway
PI3K/AKT
Target
PI3K
Related Products
Related Products
Scientific Resources
Product Documentation
Find supporting information and directions for use in the Product Information Sheet or explore additional protocols below.
Document Type
Product Name
Catalog #
Lot #
Language
Document Type
Product Information Sheet
Product Name
3-Methyladenine
Catalog #
74222 Lot #
All Language
English Document Type
Safety Data Sheet
Product Name
3-Methyladenine
Catalog #
74222 Lot #
All Language
English Educational Materials (4)
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